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Cross-species cell interaction

  1. Feb 19, 2008 #1
    Not sure what the technical term for that in but could you inject mice cells (heart, liver etc) into humans without killing/harming the human?
     
  2. jcsd
  3. Feb 19, 2008 #2
    Xenotransplantation is the word used when they transplant animal organs/tissue into humans. While some organs like heart valves from pigs have been used with quite a bit of sucess, they are chemically treated first to kill any pig cells.
    There has been a lot of studies with animal transplants, most with major setbacks, infection rates seem very high. The FDA has banned non-human primate transplants, here in the USA. There is a known risk of cross-species infection.
    Any cells your body detects as "not belonging" will be attacked by your immune system.
     
  4. Feb 19, 2008 #3
    okay but could you use immune-rejection drugs, immunosuppressants, something to stop the mouse cells in the human body from being attacked? Could you transplant liver cells from another species (specifically a mouse) into a human or could you definetly not? How long ill the immune system take to attack the cells?

    So, you could recieve something from a mouse or other animal, as long as the mouse or other animal cells were deleted? But if the mouse or other animal cells were what was giving you the effect that would be useless right?
     
    Last edited: Feb 19, 2008
  5. Feb 20, 2008 #4
    It would be very useless. Rejection starts with in 72 hours. You would half to use so much anti-rejection drugs, that the human would more then likely die of secondary infections, which is often the case, even in human to human transplants.
     
  6. Feb 20, 2008 #5
    Does rejection of the cells from a different species (not an organ, but just cells) start after 72 hours? How soon before the cells/not the organ get rejected/destroyed? Does that happen as soon as they start to interact with the body?

    thanks
    (not starting anymore threads)
     
  7. Feb 20, 2008 #6
    Individuals will vary on the amount of time, depending on their immune system. Rejection can start within hours and up to 72 hours later. The body pretty much views all the invading cells the same, it will boost the white blood cell count, depending on its need.
     
  8. Feb 21, 2008 #7
    I guess I thought that if the mouse liver cells were given to a human the human might be able to regenerate since I read this article (haven't verified everything in it) but stem cells mutate & degrade with time anyways right and they're not sure what is responsible for the abiitity to regenerate? and the mice can't regenerate/regrow their brains anyway so Im not so interested in it anymore if it can't stop brain degeneration

    It's a miracle: mice regrow hearts SCIENTISTS
    have created "miracle mice" that can regenerate amputated limbs or
    damaged vital organs, making them able to recover from injuries that
    would kill or permanently disable normal animals.The experimental animals are unique among mammals in their ability to regrow their heart, toes, joints and tail. And
    when cells from the test mouse are injected into ordinary mice, they
    too acquire the ability to regenerate, the US-based researchers say. Their
    discoveries raise the prospect that humans could one day be given the
    ability to regenerate lost or damaged organs, opening up a new era in
    medicine. Details of the research will be presented next week
    at a scientific conference on ageing titled Strategies for Engineered
    Negligible Senescence, at Cambridge University in Britain. The
    research leader, Ellen Heber-Katz, professor of immunology at the
    Wistar Institute, a US biomedical research centre, said the ability of
    the mice at her laboratory to regenerate organs appeared to be
    controlled by about a dozen genes. Professor Heber-Katz says
    she is still researching the genes' exact functions, but it seems
    almost certain humans have comparable genes. "We have
    experimented with amputating or damaging several different organs, such
    as the heart, toes, tail and ears, and just watched them regrow," she
    said. "It is quite remarkable. The only organ that did not grow back was the brain. "When
    we injected fetal liver cells taken from those animals into ordinary
    mice, they too gained the power of regeneration. We found this
    persisted even six months after the injection." Professor
    Heber-Katz made her discovery when she noticed the identification holes
    that scientists punch in the ears of experimental mice healed without
    any signs of scarring in the animals at her laboratory. The
    self-healing mice, from a strain known as MRL, were then subjected to a
    series of surgical procedures. In one case the mice had their toes
    amputated -- but the digits grew back, complete with joints. In
    another test some of the tail was cut off, and this also regenerated.
    Then the researchers used a cryoprobe to freeze parts of the animals'
    hearts, and watched them grow back again. A similar phenomenon was
    observed when the optic nerve was severed and the liver partially
    destroyed. The researchers believe the same genes could confer
    greater longevity and are measuring their animals' survival rate.
    However, the mice are only 18 months old, and the normal lifespan is
    two years so it is too early to reach firm conclusions. Scientists
    have long known that less complex creatures have an impressive ability
    to regenerate. Many fish and amphibians can regrow internal organs or
    even whole limbs. The Sunday Times
    ________________________________
     
    Last edited: Feb 22, 2008
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