This is a concept that has always eluded me. I'm a Biologist who works in the Pharmaceutical Industry and I need to get a better understanding of Biophysics with respect to enzymology, specifically with regards to crystallography, electron microscopy, and catalytic site binding physics. I Know I can go to Bio sites for the basics but I want a more mathematical description of what I see. That's why I came here. To be real specific, I wish to find a mathematical prediction of the potential binding energies of various amino acid substitutions critical for substrate binding within the catalytic site of a reductase.