Main Question or Discussion Point
At a high shear rate, red blood cells become elongated and oriented in one direction, facilitating smooth blood flow. However, at a high enough shear rate, the cells will become so strained that a part of the cell membrane pinches off. This often occurs in poorly designed medical devices that keep blood moving through the body during surgery. These membrane vesicles aren't filtered out once the blood passes from the machine back into the body, so my question is, what are the consequences of having these pieces of cell membrane floating around in the circulation?