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Degeneration of injured cells: granules in cloudy swelling
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[QUOTE="Andrew Mason, post: 6073221, member: 15795"] These stress granules are RNA-protein aggregates. The granules appear to be associated with the absence of RNA binding proteins in the nucleus and the accumulation of them in granular form in the cell cytoplasm. Granules in brain cells are associated with certain neurological diseases such as ALS and certain forms of dementia: see: [URL]https://www.cell.com/fulltext/S0092-8674(13)00946-X[/URL] [URL]https://academic.oup.com/brain/article/141/5/1236/4985461[/URL] [URL]https://mcb.asm.org/content/26/15/5744[/URL] A recent paper from the University of Saskatchewan associates extra-nuclear cytoplasmic granules of a defective RNA binding protein (hnRNP A1) with multiple-sclerosis (see:[URL]https://www.ncbi.nlm.nih.gov/pubmed/30190085[/URL]). The appearance of these RNA-protein granules seems to be part of a natural regulatory process that allows a cell to recover when stressed: [URL]https://mcb.asm.org/content/mcb/26/15/5744.full.pdf[/URL] AM [/QUOTE]
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Degeneration of injured cells: granules in cloudy swelling
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