It's a good guess. There's no reason to expect an anhydride reaction to be vastly different for primary alcohols and secondary alcohols. The only time this would be a factor is if there were some extreme steric hindrance that made the secondary alcohol reaction kinetically or thermodynamically prohibitive (but not the first).phish said:When a primary alcohol like methanol reacts with trifluoroacetic anhydride it forms methyl trifluoroacetate, but what 2 butanol form with it? I tried and got sec-butyl trifluoroacetate -this was sort of a guess.
Difficult organic reactions can be challenging due to a variety of factors, such as the presence of multiple functional groups, steric hindrance, and the need for precise reaction conditions or reagents.
To improve the yield of a difficult organic reaction, it is important to carefully choose the appropriate reaction conditions, optimize the reaction time and temperature, and use high-quality reagents. Purification techniques, such as column chromatography, can also help improve the yield.
Some common strategies for overcoming difficult organic reactions include using protecting groups, changing the reaction solvent, using catalysts, and employing novel reaction mechanisms.
Troubleshooting a difficult organic reaction involves carefully analyzing the reaction conditions and identifying potential sources of error, such as impure reagents or incorrect reaction temperatures. Making small changes to the reaction conditions and systematically testing them can help identify the problem and improve the reaction yield.
Yes, there are many resources available for learning about difficult organic reactions, including textbooks, scientific journals, and online databases. Additionally, attending conferences and workshops can provide valuable insight and tips for successfully performing difficult organic reactions.