I have a question regarding the dilution of a pharmaceutical. I need to provide subjects in a study with a certain amount of drug (1200 mg), and there is 3.3 g in 5 mL of the preformed solution. Since I will require about 1.82 mL to achieve the necessary amount of drug (1200 mg), should I just give 1.82 mL dissolved in 250 mL of water or would I be better off to dilute the concentrated standard solution and dissolve a larger volume of diluted standard in a smaller amount of water? Basically, I am wondering: (1) will a small volume of 1.82 mL be delivered to the subject without significant loss to remnants in the bottle? (2) does diluting the concentrated standard by a factor of 10 and then transferring 18.2 mL of standard to a water bottle for administration improve the chance of the subject receiving the required amount of drug (1200 mg)? (3) does dilution have no effect and the risks of loss to transfer error and remnants in containers (water bottle) exist equally no matter what? Thank you in advance to anyone willing to provide some insight. Also, feel free to ask for more information if I have left anything out.