Does ppGpp Inhibit DNA Replication and Transcription in Prokaryotic Cells?

[rockind78]

I am interested in knowing if ppGpp plays a role, direct or indirect, in inhibition of DNA replication and transcription in prokaryotic cells. I can't find anything direct, but it would be my guess that in times of amino acid starvation, the cell won't actively divide, or transcribe any RNA.

 

[Monique]

Ok, first I had to look up what ppGpp is..

ppGpp is a chemical which some bacteria produce under various conditions such as nutrient deficiency, and is made by an enzyme encoded by the rel A gene.

Now find out its function..

 

[Monique]

Btw: ppGpp is Guanosine tetraphosphate :) I was wondering, who names a chemical ppGpp :)

 

[Monique]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed" is the ultimate source of scientific publications.

http://www.ncbi.nlm.nih.gov/entrez/...e&db=PubMed&list_uids=11162084&dopt=Abstract"

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