Well, that is interesting.. how does a transcription factor cause a cell to stay pluripotent? What cascade would be affected.. maybe an inhibitor of differentiation is synthesized?
I wonder what would happen if they specifically would target Oct3/4 for therapy, all our natural stem cells (which are pluri or toti? potent) would start differentiating. Wouldn't such therapy be very toxic? Did they already look for expression of the gene in normal tissues?
I am thinking about bone marrow and basal epithelial cells in particular..
Do you know off the top of your head how they found this trancription factor, Ian?
I find it remarkable that they found a trancription factor and not a protein, since transcription factors are present in the cell at very low concentrations..
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