Enhancers and response elements

In summary, response elements are upstream sequences that can greatly increase transcription rates of genes even though they may be far upstream or downstream from the promoter they stimulate.
  • #1
rockind78
78
0
What is the difference exactly? Thanks!
 
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  • #2
Here the definition:

Enhancers
Cis acting DNA sequences that can greatly increase the transcription rates of genes even though they may be far upstream or downstream from the promoter they stimulate.
http://fred.hmc.psu.edu/ds/retrieve/fred/meshdescriptor/D020218 [Broken]

responce elements
Nucleotide sequences, usually upstream, which are recognized by specific regulatory transcription factors, thereby causing gene response to various regulatory agents. These elements may be found in both promoter and enhancer regions.
http://www.geneed.com/glossary/r/index.html

The differemce are not easy to see because they sound the same but the specificity is important. A responce element can have a role in repression of a gene whereas enhancers only stimulates the production. Responce elements are only upstream of a gene and will have a effect on the binding and action of RNA polymerase.
 
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  • #3
Originally posted by iansmith
Responce elements are only upstream of a gene and will have a effect on the binding and action of RNA polymerase.
Why are response elements only upstream? According to the link response elements can both be in the promotor and enhancer regions, enhancer regions can both be up or downstream of a promotor.. :)

For instance: if a molecule binds downstream and causes the DNA to loop a certain way, the polymerase can't go further and will be released. That is how stop signals in bacteria work right?
 
  • #4
I don't know, but in my field enhancers can also repress. They sometimes call them repressors, but sometimes not. It is all about combinatorial control anyway.
 
  • #5
Originally posted by Monique
Why are response elements only upstream?

my mistake, should of said mostly

Originally posted by Monique
[BFor instance: if a molecule binds downstream and causes the DNA to loop a certain way, the polymerase can't go further and will be released. That is how stop signals in bacteria work right? [/B]

Yeah but the gene has been transcribed whereas with these elements will stop or increase expression.
 
  • #6
Originally posted by iansmith
Yeah but the gene has been transcribed whereas with these elements will stop or increase expression.
I was just giving proof of concept if such elements were somewhere within a gene, a truncated product will be synthesized and rapidly degraded..
 
  • #8
That does look good. If you don't get it let me know.
 
  • #9
4pm: It printed! Stupid computers here..

Hm, this article looks usefull :) I'll try to stay awake in the train this time..

ps. how do they get an article to be 4 Mb? The figures are only 55 kb each.. crazy.
 
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What are enhancers and response elements?

Enhancers and response elements are DNA sequences that play a critical role in regulating gene expression. Enhancers are sequences that can increase the transcription of a gene, while response elements are sequences that can activate or repress the expression of a gene in response to certain signals or stimuli.

How do enhancers and response elements work?

Enhancers and response elements work by interacting with specific proteins, such as transcription factors, that bind to these sequences and regulate gene expression. They can also interact with other regulatory elements to form complex networks that control the timing and level of gene expression.

What is the difference between enhancers and response elements?

The main difference between enhancers and response elements is their function. Enhancers are involved in increasing gene expression, while response elements can both activate and repress gene expression in response to specific signals or stimuli.

Where are enhancers and response elements located?

Enhancers and response elements can be located anywhere in the genome, including within the coding region of a gene or far away from the gene they regulate. They can also be located on the same chromosome as the gene or on a different chromosome.

Can enhancers and response elements be mutated?

Yes, enhancers and response elements can be mutated, which can lead to changes in gene expression. Mutations can alter the binding of regulatory proteins to these sequences, resulting in either increased or decreased gene expression. This can have important implications for development, disease, and other biological processes.

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