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Enhancers and response elements

  1. What is the difference exactly? Thanks!
     
  2. jcsd
  3. iansmith

    iansmith 1,430
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    Here the definition:

    Enhancers
    http://fred.hmc.psu.edu/ds/retrieve/fred/meshdescriptor/D020218

    responce elements
    http://www.geneed.com/glossary/r/index.html

    The differemce are not easy to see because they sound the same but the specificity is important. A responce element can have a role in repression of a gene whereas enhancers only stimulates the production. Responce elements are only upstream of a gene and will have a effect on the binding and action of RNA polymerase.
     
  4. Monique

    Monique 4,700
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    Why are response elements only upstream? According to the link response elements can both be in the promotor and enhancer regions, enhancer regions can both be up or downstream of a promotor.. :)

    For instance: if a molecule binds downstream and causes the DNA to loop a certain way, the polymerase can't go further and will be released. That is how stop signals in bacteria work right?
     
  5. I don't know, but in my field enhancers can also repress. They sometimes call them repressors, but sometimes not. It is all about combinatorial control anyway.
     
  6. iansmith

    iansmith 1,430
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    my mistake, should of said mostly

    Yeah but the gene has been transcribed whereas with these elements will stop or increase expression.
     
  7. Monique

    Monique 4,700
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    I was just giving proof of concept if such elements were somewhere within a gene, a truncated product will be synthesized and rapidly degraded..
     
  8. Monique

    Monique 4,700
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  9. That does look good. If you don't get it let me know.
     
  10. Monique

    Monique 4,700
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    4pm: It printed!!!!! Stupid computers here..

    Hm, this article looks usefull :) I'll try to stay awake in the train this time..

    ps. how do they get an article to be 4 Mb????? The figures are only 55 kb each.. crazy.
     
    Last edited: Feb 12, 2004
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