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Epigenetics i.e. gene regulation

  1. Jun 5, 2010 #1

    cph

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    Might a different approach to epigenetics relate to first opening up attack on regional genome sites.
    For example, perhaps there are release points - levers where siRNA might push in stericly, and further open up such site. Then next transcription factor further wedges in. Then adding co-factors to form complex, that further wedges in; further opening up genome to specific action. Hence a multi-step more physical dynamic wedging and opening up, for gene activation. Yeast is already open chromosomal pattern. So further out on evolutionary tree, chromatin compaction would seem a way of controlling and regulating selective gene expression. In contrast to above, might specific base sequences lead to internal genome destabilization i.e. favoring opening up of genome? Might a combination of internal and external genome destabilization be at work? How to test: Perhaps flood a system with siRNA (regulatory?) and assay gene expression by measuring protein concentration.
     
  2. jcsd
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