The trouble with epistemology is that it is tightly bound to metaphysics, and vice versa of course. Your epistemology is determined by your metaphysics, and your metaphysics is determined by your epistemology. The result of this indeterdependency is an evolutionary dynamic. Any particular system of epistemologies is based upon a set of suppositions the violation of which destroys the epistemological system. It becomes incoherent. There is only so much that a particular epistemological system can teach within a given discipline. As an example let us examine the method of producing computer chips. To maintain Moore's Law new methods are periodically required to produce faster chips. The old techniques have either reached their theoritical limit or their cost effectiveness. The underlying problem with any metaphysics/epistemology is that as its basis, some possibilities are excluded. None can answer all questions, some questions must be denied. When it comes to a Theory of Everything to answer means to become God. We are finite. Accept it. The infinite can not come from the finite. If there were to be a TOE, existence would expend greatly. But then a entirely new set of questions would arrise, which we could not conceive of today.