DG = -RTln(K) always valid? Hi, For a reaction at equilibrium, A<==>B, then the free energy can be defined as DG = -RTln(K), where K = /[A]. This is fine for an isolated equilibrium. But suppose that the system is not isolated so that A<==>B--->C for example, or if is part some even more complicated kinetic scheme. Does the relationship for DG still hold? Please help with this one, am getting conflicting advice from different people! Ta.