True life extension, the kind that will give us a thousand healthy years is a problem mired in complexity so many orders of magnitude deep that it's difficult to imagine, although not impossible, that we will come to the solution through merely supplement cocktails, gene therapy, regeneration/transplants etc... What might do the trick is the massively parallel problem solver we call evolution. By exerting a very specific evolutionary pressure, in this case "minimum age of reproduction", evenly across the entire population, and very slowly -and by slowly I mean glacially, increase the minimum age of reproduction, we can attain a truly vibrant and healthy thousand+ year lifespan for our descendants. This would of course be a multi-generational megaproject that would require the participation of everyone for tens if not hundreds of thousands of years. However, if this process were augmented with future breakthroughs in technologies like gene mapping and massive bio-informatics database analyses (I just pulled that one out of my backside), we could reach our goal much quicker. I realize the population compliance part is not feasable, but would this technically work?