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Folding kinetics

  1. Jun 3, 2012 #1
    1. The problem statement, all variables and given/known data
    Folding can be described as transition between the native and unfolded state. In increasing concentrations of denaturant, a fold disintegrates with a rate

    lnKU = ln KU H20 - m ku [denat]

    when the concentration of denaturant is above that needed to unfold 50 % of protein. Conversely folding takes place with rate

    lnKf = ln Kf H2O - m ku [denat]

    when the concentration of denaturant is below that needed to unfold 50 % of protein.
    Write an equation for the observed rate constant ln kobs and plot it (Chevron plot) as a function of denaturant concentration.
    How do you determine from the figure kfH2O?
    How will the Chevron plot change when a mutation will affect the transition state?


    2. Relevant equations



    3. The attempt at a solution
     
  2. jcsd
  3. Jun 4, 2012 #2

    epenguin

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    What looks like an identical post dated Jun 2 was answered on Jun 3
     
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