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From nucleotides to DNA

  1. Feb 13, 2006 #1
    Given high and approximately equal concentrations of nucleotides Adenine, Cytosine, Guanine and Thymine in aqueous solution, how readily could a simple DNA molecule form there?
  2. jcsd
  3. Feb 13, 2006 #2


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    You'd need the backbone sugars, too.

    - Warren
  4. Feb 14, 2006 #3


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    To be precise, it's a sugar-phosphate backbone (alternating), where every sugar has a nucleotide base attached.
  5. Feb 14, 2006 #4
    Alright, make the solution a balance of appropriate sugars, phosphates and nucleotides.
  6. Feb 14, 2006 #5


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    I don't think this would auto-assemble into anything you would recognize as DNA. Nirenberg's famous auto-assembly of poly-uracyl RNA used a starter "sap", the crushed cytoplasm from a bacterium, along with the test tube of uracyl. See http://history.nih.gov/exhibits/nirenberg/HS4_polyU.htm
  7. Feb 15, 2006 #6

    In my work (for a mental health line), I refer people to NIH quite often. Thanks for the link to that wonderful story, of which I was unaware until now.
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