Can Nucleotides Spontaneously Form DNA in Aqueous Solution?

  • Thread starter Loren Booda
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In summary, the conversation discusses the possibility of a simple DNA molecule forming in a solution with high concentrations of nucleotides Adenine, Cytosine, Guanine, and Thymine. It is mentioned that a sugar-phosphate backbone is necessary for DNA formation, along with appropriate sugars and phosphates. The idea of auto-assembly is also brought up, using Nirenberg's famous experiment with poly-uracyl RNA. However, it is concluded that this solution would not likely result in recognizable DNA formation. The conversation also mentions the use of NIH for mental health resources.
  • #1
Loren Booda
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Given high and approximately equal concentrations of nucleotides Adenine, Cytosine, Guanine and Thymine in aqueous solution, how readily could a simple DNA molecule form there?
 
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  • #2
You'd need the backbone sugars, too.

- Warren
 
  • #3
To be precise, it's a sugar-phosphate backbone (alternating), where every sugar has a nucleotide base attached.
 
  • #4
Alright, make the solution a balance of appropriate sugars, phosphates and nucleotides.
 
  • #5
I don't think this would auto-assemble into anything you would recognize as DNA. Nirenberg's famous auto-assembly of poly-uracyl RNA used a starter "sap", the crushed cytoplasm from a bacterium, along with the test tube of uracyl. See http://history.nih.gov/exhibits/nirenberg/HS4_polyU.htm
 
  • #6
selfAdjoint,

In my work (for a mental health line), I refer people to NIH quite often. Thanks for the link to that wonderful story, of which I was unaware until now.
 

1. What are nucleotides?

Nucleotides are the building blocks of DNA. They are small molecules that contain a sugar, a phosphate group, and a nitrogenous base. The four different nitrogenous bases found in nucleotides are adenine, guanine, cytosine, and thymine.

2. How do nucleotides form DNA?

Nucleotides bond together through covalent bonds to form long chains, which are then arranged in a double helix structure to create DNA. The specific sequence of nucleotides determines the genetic information of an organism.

3. What is the function of DNA?

DNA carries the genetic instructions for the development, functioning, and reproduction of all living organisms. It is responsible for determining an organism's traits and characteristics.

4. How is DNA replicated?

DNA replication is the process by which cells copy their genetic information before cell division. It begins with the unwinding of the double helix structure and the separation of the two DNA strands. Each strand then serves as a template for the synthesis of a new complementary strand, resulting in two identical DNA molecules.

5. What happens when there are mutations in DNA?

Mutations are changes in the genetic sequence of DNA. They can occur spontaneously or be caused by external factors such as radiation or chemicals. Depending on the type and location of the mutation, it can have no effect, a beneficial effect, or a harmful effect on an organism.

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