Can someone tell me some of the hypothesized causes of why a cell will enter into the resting G0 phase (that's, G-zero phase) during mitosis? My AP bio. textbook doesn't say why the cell will sometimes pause before DNA replication.
The role of the G-0 phase is to stop proliferation because can you imagine if the CNS you always regenarated its cell pool. We probably have memory problem and other problem due to losing connection.from http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=153779
In vitro studies have examined the link between aberrant cell cycle reentry and neuronal cell death. These results demonstrate that although at least some postmitotic neurons retain the capacity to respond to growth factors by reentering into the cell cycle, such stimulation causes apoptosis rather than proliferation.
That sentence is very misleading. G1 is a resting phase before replication, it is part of the cycle of mitosis. G0 is a specialized state, not part of mitosis, for when cell doesn't need to replicate.Cells often pause in G-1 before replication and enter a resting state called G-0 phase
Nice...a 6 year old necro-post!Does anyone have examples of a few different cells that go into G0 Phase? It doesn't say in my text book and my class is suppose to find these examples for extra credit.