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- TL;DR Summary
- Fitness landscapes are defined as the control (e.g., switch on/off) of protein coding DNA by regulatory (non-protein coding) DNA. Mathematical map modeling has improved our understanding of the landscape and its consequences.
Popular science version https://phys.org/news/2022-03-oracle-evolution-gene.html
Nature paper:
Aviv Regev, et al, "The evolution, evolvability and engineering of gene regulatory DNA", Nature (2022).
Abstract only because of paywall:
DOI: 10.1038/s41586-022-04506-6.
www.nature.com/articles/s41586-022-04506-6
The concept here is being able to interpret the maps in terms of predicting likelihoods of good/ bad results from changes DNA protein synthesis. There are several genetically associated diseases -- "bad results" -- mentioned in the pop sci article.
Mutations that occur in regulatory (non-coding) DNA play an important role in determining the fitness landscape. They may arise in the parent and are passed on to offspring, or arise in the individual -- both often occur as a result of environmental factors.
This is an example of 'Heredity Environment Interaction' that you learn about in freshman Biology. An often used example is phenotypic plasticity.
Nature paper:
Aviv Regev, et al, "The evolution, evolvability and engineering of gene regulatory DNA", Nature (2022).
Abstract only because of paywall:
DOI: 10.1038/s41586-022-04506-6.
www.nature.com/articles/s41586-022-04506-6
The concept here is being able to interpret the maps in terms of predicting likelihoods of good/ bad results from changes DNA protein synthesis. There are several genetically associated diseases -- "bad results" -- mentioned in the pop sci article.
Mutations that occur in regulatory (non-coding) DNA play an important role in determining the fitness landscape. They may arise in the parent and are passed on to offspring, or arise in the individual -- both often occur as a result of environmental factors.
This is an example of 'Heredity Environment Interaction' that you learn about in freshman Biology. An often used example is phenotypic plasticity.
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