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Genetic mechanisms of critical illness in Covid-19 - Nature Magazine
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[QUOTE="Tom.G, post: 6430759, member: 581973"] [b]Genetic mechanisms of critical illness in Covid-19[/b] 33 pages. Free PDF download at: [URL]https://www.nature.com/articles/s41586-020-03065-y_reference.pdf[/URL] "...we found evidence in support of a causal link from low expression of [I]IFNAR2[/I], and high expression of [I]TYK2[/I], to life-threatening disease; transcriptome-wide association in lung tissue revealed that high expression of the monocyte/macrophage chemotactic receptor [I]CCR2[/I] is associated with severe Covid-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms, and mediators of inflammatory organ damage in Covid-19. Both mechanisms may be amenable to targeted treatment with existing drugs." Cheers, Tom [/QUOTE]
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Genetic mechanisms of critical illness in Covid-19 - Nature Magazine
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