(adsbygoogle = window.adsbygoogle || []).push({}); 1. The problem statement, all variables and given/known data

Have to determine permeabilities [tex]\alpha[/tex] and [tex]\beta[/tex] (P_{Na}/P_{K}and P_{Cl}/P_{K})

as well as internal concentrations of Na+, K+ and Cl-

I have calculated different membrane voltages according to the external concentration (when altering one ion, the other two were set to zero).

2. Relevant equations

Ki = {(A2 + 4Co2)1/2 + A}/2

ψ = (kT/q) ln (Co/Ki)

and GHK equation:

VR = kT/qln {Ko*+*αNao*+*βCli/Ki+*αNai*+*βClo}

3. The attempt at a solution

I am having trouble calculating the internal concentrations for K, Cl and Na. I have the membrane voltages and the concentrations between 0mM and 300mM in 5mM increments.

I think once I am able to calculate that, I might be able to figure out the rest.

Thanks

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# Homework Help: GHK equation

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