Dismiss Notice
Join Physics Forums Today!
The friendliest, high quality science and math community on the planet! Everyone who loves science is here!

Haemolysis and coagulation

  1. Jun 28, 2004 #1
    My text book says that thromboplastin which is produced by damaged tissues acts as the catalyst to convert prothrombin into thrombin. However, I have seen on the internet references to a Prothrombin activator being the catalyst and that this results from thromboplastin and other factors. Which is true? What really does happen?
    Thanks.
     
  2. jcsd
  3. Jun 28, 2004 #2

    iansmith

    User Avatar
    Staff Emeritus
    Science Advisor
    Gold Member

    Coagulatuion may begin from any of the coagulation factors from different pathway depending on the extent of damage and time of the signalling. Both the test book and the internet references are more or less rigth. http://www.biocarta.com/pathfiles/h_intrinsicPathway.asp [Broken]

    thromboplastin: an enzyme liberated from blood platelets that converts prothrombin into thrombin as blood starts to clot

    prothrombin - a protein in blood plasma that is the inactive precursor of thrombin

    http://www.thefreedictionary.com/coagulation factor
     
    Last edited by a moderator: Apr 21, 2017 at 7:04 AM
  4. Jun 29, 2004 #3
    So, which is it which converts prothrombin to thrombin? Thromboplastin or prothrombin activator? Thanks.
     
  5. Jun 29, 2004 #4
    Also, apparently platelet factors are released when platelets lyse or burst. hy do they burst?
     
  6. Jun 29, 2004 #5

    iansmith

    User Avatar
    Staff Emeritus
    Science Advisor
    Gold Member

    Both compound convert prothrombin but using different pathways.

    http://www.labtestsonline.org/images/coag_cascade.pdf [Broken]

    Again different pathways comes into play but briefly you have antibodies, complement and bacterial factors.
     
    Last edited by a moderator: Apr 21, 2017 at 7:05 AM
  7. Jun 29, 2004 #6
    Why do they burst?
    Also, what causes the reflex of vascoconstriction when we are cut?
     
  8. Jun 29, 2004 #7

    Monique

    User Avatar
    Staff Emeritus
    Science Advisor
    Gold Member

    Platelets release their granula upon activation, they don't actually burst. The vascoconstriction is mediated by factors released by the damaged tissue and the activated platelets.
     
Know someone interested in this topic? Share this thread via Reddit, Google+, Twitter, or Facebook




Similar Discussions: Haemolysis and coagulation
  1. Blood coagulation (Replies: 1)

Loading...