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Haemolysis and coagulation

  1. Jun 28, 2004 #1
    My text book says that thromboplastin which is produced by damaged tissues acts as the catalyst to convert prothrombin into thrombin. However, I have seen on the internet references to a Prothrombin activator being the catalyst and that this results from thromboplastin and other factors. Which is true? What really does happen?
    Thanks.
     
  2. jcsd
  3. Jun 28, 2004 #2

    iansmith

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    Coagulatuion may begin from any of the coagulation factors from different pathway depending on the extent of damage and time of the signalling. Both the test book and the internet references are more or less rigth. http://www.biocarta.com/pathfiles/h_intrinsicPathway.asp

    thromboplastin: an enzyme liberated from blood platelets that converts prothrombin into thrombin as blood starts to clot

    prothrombin - a protein in blood plasma that is the inactive precursor of thrombin

    http://www.thefreedictionary.com/coagulation factor
     
  4. Jun 29, 2004 #3
    So, which is it which converts prothrombin to thrombin? Thromboplastin or prothrombin activator? Thanks.
     
  5. Jun 29, 2004 #4
    Also, apparently platelet factors are released when platelets lyse or burst. hy do they burst?
     
  6. Jun 29, 2004 #5

    iansmith

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    Both compound convert prothrombin but using different pathways.

    http://www.labtestsonline.org/images/coag_cascade.pdf

    Again different pathways comes into play but briefly you have antibodies, complement and bacterial factors.
     
  7. Jun 29, 2004 #6
    Why do they burst?
    Also, what causes the reflex of vascoconstriction when we are cut?
     
  8. Jun 29, 2004 #7

    Monique

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    Platelets release their granula upon activation, they don't actually burst. The vascoconstriction is mediated by factors released by the damaged tissue and the activated platelets.
     
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