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Haldane's Dilemma

  1. Oct 25, 2006 #1
    This paper states that rates of beneficial mutations can not account for the time that has passed between the first homonids and humans. Has this been resolved? How?
  2. jcsd
  3. Oct 25, 2006 #2


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    Staff: Mentor

    I think this statement on the wiki page sums it up "The neutrality and factual accuracy of this article are disputed."

    The rebutal - "Haldane's "cost of natural selection" stemmed from an invalid simplifying assumption in his calculations. He divided by a fitness constant in a way that invalidated his assumption of constant population size, and his cost of selection is an artifact of the changed population size. He also assumed that two mutations would take twice as long to reach fixation as one, but because of sexual recombination, the two can be selected simultaneously and both reach fixation sooner. With corrected calculations, the cost disappears (Wallace 1991; Williams n.d.). "

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