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Help me formulate a formuler

  1. Jul 12, 2005 #1
    If a tumor cell grows with rate m, and dies with rate n (m>n), their population number is P, after tme t, how can set up a mathematical fomuler for growth ? If i also have data from 100 patients, is it useful ?
    Thanks
     
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  3. Jul 12, 2005 #2

    HallsofIvy

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    Essentially you are saying that the tumor cell grows with rate m-n so that you have the differential equation P'(t)= (m-n)P(t). Exponential functions have the property that their rate of change is a multiple of their value so P(t)= Ce(m-n)t.
    I'm not sure what data you have but if you have P(t) for at least 3 different times for each patient, you can use the data to determine C, m, and n for each patient. Just put the values for t and P(t) into the equation and you will have three equations to solve for C, m, and n. If you have more than 3 "data points" for a patient, you can check how well those values correspond to P(t) calculated from the formula to see how good that model is. Of course, it would be interesting to see if m and n are at least approximately the same for the different patients.
     
  4. Jul 12, 2005 #3
    If Purgum meant that rate is m-n, the differential eqn would be P'(t)=m-n.

    However, I think, the data given is incomplete. The rate should be dependent in some way on the number of tumour cells; for example, the growth rate proportional to the no of tumour cells and death rate constant. The question given as such does not seem logical.
     
  5. Jul 12, 2005 #4

    HallsofIvy

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    That's exactly what I said!
     
  6. Jul 12, 2005 #5

    EnumaElish

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    If you have lots of data, you can statistically estimate mi - ni (= net growth rate for patient i) through the regression equation:

    Pi(t+1) = bi Pi(t) + ui(t)
    where bi = mi - ni + 1 and you can test whether mi - ni > 0 by testing whether bi > 1 (that is, whether bi - 1 > 0);

    or more generally:

    Pi(t+1) = ai + bi Pi(t) + ui(t),
    where you can also test the expectation ai = 0.

    You need to check for serial autocorrelation; almost surely you will encounter positive autocorrelation (e.g. using Durbin-Watson test); if so, you'll need to correct for it.

    You can also test whether m - n is identical across patients and/or over time for each patient, by building slightly more complicated regression equations.

    Alternatively you may want to specify percentage growth rates (instead of linear as above).
     
    Last edited: Jul 12, 2005
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