High pressure chromatography?

  • Thread starter sanjuro
  • Start date
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What are the applications and advantages/disdvantages of using gas
and high pressure chromatography? Why does the pharmaceutial industry
use chromatography?

Any info would be much appreciated

Thanx
 
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Bystander

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Term paper, huh? Look for "review" articles --- Chemical Review is an obvious first place, then it's off to Chem. Abstracts, or Physics Abstracts.
 
GC and HPLC are great analytical tools. But can't be used for seperation. The pharmaceutical industry hates chromatography with a passion and would much rather take a hit with yield than not running a seperation.
 

nautica

Originally posted by Chemicalsuperfreak
GC and HPLC are great analytical tools. But can't be used for seperation. The pharmaceutical industry hates chromatography with a passion and would much rather take a hit with yield than not running a seperation.
I don't quite understand, why you even say that they can not be used for seperation. They are not meant for seperating, only for analyzing.

Nautica
 
Originally posted by nautica
I don't quite understand, why you even say that they can not be used for seperation. They are not meant for seperating, only for analyzing.

Nautica
Other forms of chromatography are commonly used for bulk seperation. They all seperate of course...
 

Bystander

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"Preparative chromatography" produces 2k hits, GC, LC, and HPLC --- analysis rather than separation? Huh? That's the analytical principle --- the separation of components from each other.

Iowa State (?) used to run a commercial separation of lanthanides; this day and age, EPA and OSHA would probably bankrupt you with disposal fees before you could fail gracefully as a consequence of an insufficient market for chromatographic separations --- it's expensive, it's a special case (cost is no object) method, and it's entirely too time consuming for accounting depts/divs.

2k hits? Obviously still around.

Edit: Google math is as peculiar as "new math," 2k = 575 by actual count.
 
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