How a signal ends?

  • #1
Ahmed Abdullah
203
3
In the presence of the signal molecules, cascades of enzyme activation take place usually by phosphorylation. When signal ceases activated enzymes (phosphorylated or dephosphorylated) are still there, so they can go on doing what they were doing before. My question is how this enzymes are deactivated after the signal ends? I am looking for basic mechanism (schematic).
 

Answers and Replies

  • #2
Ygggdrasil
Science Advisor
Insights Author
Gold Member
2021 Award
3,511
4,182
There are enzymes called phosphatases that can remove phosphates from proteins and other phosphorylated molecules. In fact, most post-translational modifications of proteins can be reversed by some enzymes (e.g. deubiquitinases remove ubiquitin, deacetylases remove acetylation, etc.).
 
  • #3
Ahmed Abdullah
203
3
There are enzymes called phosphatases that can remove phosphates from proteins and other phosphorylated molecules. In fact, most post-translational modifications of proteins can be reversed by some enzymes (e.g. deubiquitinases remove ubiquitin, deacetylases remove acetylation, etc.).

Are these phosphatase still there even when no signal is present?
Or they need to be activated or synthesized when a particular signal ends (seems very unlikely)?
 
  • #4
sameeralord
662
3
Phosphatases are always there they don't need to be synthesized. May be when there is too much product from the enzyme reaction it can act as cofactor for Phosphatase enzymes and reverse the reaction. Like negative feedback!!
 

Suggested for: How a signal ends?

Replies
14
Views
47K
Replies
7
Views
3K
  • Last Post
Replies
6
Views
4K
  • Last Post
Replies
2
Views
3K
Replies
4
Views
2K
Replies
9
Views
4K
Replies
6
Views
1K
Replies
3
Views
6K
Replies
2
Views
4K
Replies
8
Views
573
Top