enzymes are considered inactive at low tempertaures, and denatured at high temps.both these terms have different meanings, with inactive meaning enzyme having "low activation energy"and denatured meaning the enzyme is destroyed. when an enzyme is inactive, it does not lower the activation energy of a chemical reaction, and it does not react with the substrate. i am not exactly sure how the enzyme lowers the activation energy of the chemical reaction, so i am actually guessing that there is no form of lowering of activation energy when the temp is very low.please correct me if i am wrong. according to my bio teacher, she claims that an inactive enzyme has low activation energy and this can be explained using the collisive particle theory. so i am again assuming that what she meant was when the temp is too low, rate of reaction is low as the enzyme molecules are unable to lower the activation energy hence it takes a longer time for the chemical reaction to occur as the enzyme and substrate molecles need more energy to have sufficient activation energy for the chemical reaction to occur. is my theory correct? and, can someone please explain to me what it means exactly for an enzyme to be inactive, does it just purely mean that it doesnt react with the substrate? enzyme cannot be inactive at high temps right? it is denatured, right? help is really appreciated thanks!