I hold the opinion that our kind of life is ineluctably biological. If we create computer-mechanical life, we do not transition ourselves to it. Rather, we facilitate our own replacement by it. Our devices were originally conceived as our tools, what we use to extend our perceptions and our powers while we, ourselves, remain biological organisms. We are, by nature, more than our wants and our wills, and although evolution will sooner or later change us, we will remain us only so long as we remain biological.I think the most likely solution to the Fermi Paradox is the "they're made of meat" argument. We're too primitive to be considered civilized life. The universe is probably littered with animals that almost made it, but didn't. If our obsession with medicine is anything to go by, our self preservation instinct extends to our technology, and since that's a driving force of evolution of greater beings, I would expect species to embrace some sort of digital immortality not soon after it's invented. What could a being that's hundreds of thousands of years old have to talk about with an ape that can barely understand it's place in the universe.
An elite American special forces team could spy on an ancient Roman battalion without much effort, I see no reason that an alien species couldn't observe us from afar without us knowing.
There is yet room for improvement in the human kind by biological means. The major impediments are ideological, not theoretical or practical. It seems that every time someone says 'eugenics,' someone else says 'Holocaust,' and the discussion rapidly attenuates, dissolves, or mutates. The betterment of unknown billions of people yet to be born is judged to be of less importance than the present condition or the civil rights of a few millions who live now. Those future people don't get to vote on whether they shall be born strong or weak, constitutionally sound or prone to illness, with senses acute or impaired, or of great intelligence or retarded. And so what can be done, and what should be done, is never done.