Genes that Cause Human Aging: Telomeres, Klotho & Methuselah

In summary, the conversation discussed the various genes that are believed to be responsible for aging. While many people believe that the shortening of telomeres is the main reason for aging, there are other genes such as Klotho and Methuselah that also play a role. The long-standing theory of accumulation of errors in cell division causing cellular failure is also considered a major factor in aging. This theory suggests that when a large number of cells die at the same time, the tissues lose their physiological function and age. However, the exact importance of this theory in the aging process is still uncertain.
  • #1
pomkon
4
0
What genes cause aging, most people think shortening of telomeres is the main reason of aging, but I know there are more than that, like Klotho, Methuselah. But which fews are more important than others, and what else are there?
 
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  • #2
Don't forget the long standing theory that accumulation of errors in cell division which causes their failure is responsible for much of the aging.
 
  • #3
You mean that the DNA of the cells have been damaged so mush that it stops dividing, and when a lot of them are dying at the same time, the tissues are losing its phsiological function, and age? BUt why do you say for much of the aging?
 
  • #4
That's what I meant, yes, sorry if I expressed it awkwardly. With "much of the aging" I meant to say that it's been considered an important cause, although I wouldn't know just how important.
 

1. What are telomeres and how do they affect human aging?

Telomeres are the protective caps at the ends of our chromosomes that help maintain the stability and integrity of our DNA. Each time our cells divide, our telomeres shorten, eventually leading to cell death and aging. This has been linked to various age-related diseases and conditions.

2. What is the role of the Klotho gene in human aging?

The Klotho gene is involved in regulating the aging process by producing a protein that helps maintain the health and function of various organs and tissues in the body. Researchers have found that variations in this gene can affect lifespan and susceptibility to age-related diseases.

3. Is it possible to slow down the aging process by targeting these genes?

While research has shown that telomeres and the Klotho gene play a role in aging, it is not yet clear if targeting these genes can directly slow down the aging process. However, maintaining a healthy lifestyle with regular exercise and a balanced diet can help keep these genes functioning optimally.

4. What is the Methuselah gene and how does it relate to human aging?

The Methuselah gene, also known as the FOXO3 gene, has been linked to longevity and healthy aging. People with specific variations in this gene have been found to live longer and have a reduced risk of age-related diseases.

5. Are there any current treatments or interventions based on these genes for promoting healthy aging?

At this time, there are no approved treatments or interventions specifically targeting these genes for promoting healthy aging. However, ongoing research may lead to potential therapies in the future. In the meantime, maintaining a healthy lifestyle and avoiding unhealthy habits like smoking can help support healthy aging.

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