Dismiss Notice
Join Physics Forums Today!
The friendliest, high quality science and math community on the planet! Everyone who loves science is here!

Human Pituitary proteins-how to find them?

  1. Aug 18, 2005 #1
    i am looking for some human pituitary proteins for example glucocorticoid receptor. the problem is i get only the answer for human glucocorticoid receptor and not glucocorticoid receptor from human pituitary. as i know glucocorticoid receptor is different in different human locations, then how come i get glucocorticoid receptor from pituitary and not just "human glucocorticoid receptor"?

    Any help is greatly appreaciated!

    Thanks a bunch!!!
  2. jcsd
  3. Aug 18, 2005 #2


    User Avatar
    Staff Emeritus
    Science Advisor
    Gold Member

    Can you clarify what you're trying to do? Do you mean doing a literature search for information on glucocorticoid receptors, or identifying them in tissue samples you have, or getting purified protein from a supplier?

    When most people are talking about GR, they are referring to the alpha isoform, which is the one that binds glucocorticoids. There is also a beta isoform reported in the literature, but that one does not bind glucocorticoids. Recent work seems to suggest it acts in a dominant negative manner in reducing transcriptional activity of the alpha isoform (and possibly the mineralocorticoid receptors as well).

    For a review of the different isoforms and post-translational modifications of the receptor, see:
    Zhou J, Cidlowski JA. The human glucocorticoid receptor: one gene, multiple proteins and diverse responses. Steroids. 2005 May-Jun;70(5-7):407-17.

    It's the same protein no matter what tissue it's found in.
  4. Aug 19, 2005 #3
    Sorry, moonbear! I forgot the main thing. :grumpy: i am looking for the size (Da) of the human pituitary glucocorticoid receptors, but what i get is only the human glucocorticoid receptors. my question: is the size and the structure of human pituitary glucocorticoid receptors the same in any locations of our body? Are the human ovarian glucocorticoid receptors identical to human pituitary glucocorticoid receptors in siza and structure?

    Hope for any inputs!
  5. Aug 19, 2005 #4


    User Avatar
    Staff Emeritus
    Science Advisor
    Gold Member

    Yes, there is only one identified glucocorticoid receptor. The only thing that will vary from tissue to tissue, or cell to cell even, would be post-translational modifications, such as phosphorylation state.
Share this great discussion with others via Reddit, Google+, Twitter, or Facebook

Similar Threads for Human Pituitary proteins Date
High dose gamma ray exposure vs Low dose gamma ray exposure Apr 8, 2018
Another New Organ! Mar 28, 2018
Cattle Eyeworms in Humans Feb 12, 2018
Distance from the equator and human evolution Nov 29, 2017
Medical How do I stimulate my pituitary gland? Sep 7, 2014