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There is currently no official confirmation of a 6th season for Sliders in the 21st century. The original series ended in 2000 and there have been no plans announced for a new season.
Sliders was cancelled due to declining ratings and high production costs. The show also faced several creative changes and cast departures, which may have contributed to its cancellation.
There have been talks of a Sliders reboot in recent years, but nothing has been officially confirmed. Some of the original cast members have expressed interest in reprising their roles, but it remains uncertain if a reboot will actually happen.
It is unclear if the original cast members will return for a potential 6th season. Some have expressed interest in reprising their roles, while others have moved on to other projects. It would ultimately depend on their availability and interest in returning to the show.
As of now, there is no new information on a 6th season for Sliders. The show's creator, Tracy Tormé, has continued to express interest in bringing the show back, but there have been no official announcements or updates on its development.