This is an academic question - out of curiosity - not so much about actually getting relief. I've got a nasty mosquito bite on the under side of my forearm. It's a Muskoka mosquito - the big ones with the really itchy bites. Even if I don't scratch it, it still rubs on everything from desk edges to couch cushions. It is transferring the itch along my nerve to the knuckle on my thumb, which is now also very itchy. I am applying an anti-itch cream to the bite itself, but it's not enough to stop the itching. My knuckle still itches terribly. So here's my question: Does the application of an anti-itch cream to the site of the deferred itch have any effect? i.e. does an anti-itch cream only work against the actual site of nerve inflammation? Or can it work on a secondary spot that is only irritated by proxy?