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Medical Insulin dependent glucose uptake

  1. Aug 17, 2016 #1
    We know that type 2 diabetes is caused by insulin insufficiency/resistance.

    Normally Insulin causes GLUT4 in the liver and muscle/adipose cells to surface at their cell membrane, to facilitate the transport of glucose from the circulating blood. Type2DM lacks this action and hence glucose don't get into cells and thus keep circulating in the blood.

    But there are other glucose transporters like GLUT1, GLUT2, GLUT3 etc which are not dependent on insulin to cause the suffusing of glucose into the cells. Ie., they facilitate transporting glucose (although in lesser quantity) into these cells even in the absence of insulin. Isn't it?

    Is it right to assume that to consume the ingested glucose, insulin is not everything but may be important.

    My question is, how much of our body's glucose clearance is dependent on insulin only, in ratio? (Or not dependent on insulin, if we look at it in another way) For example, is 70% of our glucose clearance is dependent on insulin/GLUT4 axis? Or is it 90%, or is it 20% only?

    This question is to understand, why do we focus only on insulin in diabetes type2DM, when we have other pathways to consume glucose in our cells?

  2. jcsd
  3. Aug 22, 2016 #2
    Thanks for the thread! This is an automated courtesy bump. Sorry you aren't generating responses at the moment. Do you have any further information, come to any new conclusions or is it possible to reword the post? The more details the better.
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