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E(R)=-A/(R^2)+B/(R^10)

The atoms form a stable molecule with an inter- nuclear distance of 0.3nm and a dissociation energy of 4 eV.

a) Determine A and B.

b) Calculate the force required to break the molecule. What is the critical distance between the nuclei for which this occurs?

I have two variables which I need to solve for but one equation. My teacher said try taking the derivative and you can then isolate one variable. I don't understand how or why you can so this. Any help would be greatly appreciated.