- #1
Mr_Bojingles
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Is it possible to synthesize adrenaline in the lab?
Is it possible to synthesize adrenaline in the lab?
- Thread starter Mr_Bojingles
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In summary, the conversation discusses the possibility of synthesizing adrenaline in the lab and proposes a potential method using starting materials such as 2-Chloro-1-(3,4-dihydroxyphenyl)ethanone and methyl amine. The reduction process is also mentioned and it is noted that enzymes are able to do this chemistry more efficiently than in a lab setting.
- #2
gravenewworld
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Mr_Bojingles said:
Yes it shouldn't be taht hard.
- #3
JGM_14
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our body does it all the time 
- #4
gravenewworld
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I did a search for possible starting materials and looked at the cost vs. how many steps for a possible synthesis and you could do it this way:
Buy 2-Chloro-1-(3,4-dihydroxyphenyl)ethanone, 97% (500 g, $283 Alpha Aesar)
Do a substitution of the chlorine with methyl amine (use a large excess of methyl amine).
Reduce the carbonyl stereoselectively using 1H,3H-Pyrrolo[1,2-c][1,3,2]oxazaborole, tetrahydro-1-methyl-3,3-diphenyl-, (S)- with Borane Dimethyl sulfide complex in THF.
I've done the reduction before, it works pretty well (>75% yield)
That should give you adrenaline.
Buy 2-Chloro-1-(3,4-dihydroxyphenyl)ethanone, 97% (500 g, $283 Alpha Aesar)
Do a substitution of the chlorine with methyl amine (use a large excess of methyl amine).
Reduce the carbonyl stereoselectively using 1H,3H-Pyrrolo[1,2-c][1,3,2]oxazaborole, tetrahydro-1-methyl-3,3-diphenyl-, (S)- with Borane Dimethyl sulfide complex in THF.
I've done the reduction before, it works pretty well (>75% yield)
That should give you adrenaline.
- #5
quetzalcoatl9
- 538
- 1
JGM_14 said:our body does it all the time
that doesn't means it's easy, in fact it's generally the opposite. enzymes regularly do chemistry that we can't dream of doing in the lab.
- #6
JGM_14
- 158
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quetzalcoatl9 said:
Point taken.
- #7
brewnog
Science Advisor
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Apparently, it was first synthesised in the lab in 1904 by Freidrich Stolz...
- #8
Remnant
- 19
- 0
Hint: Meth is 1 atom away from adrenaline..
1. Can adrenaline be synthesized in the lab?
Yes, adrenaline can be synthesized in the lab using various chemical reactions and processes.
2. Why would someone want to synthesize adrenaline in the lab?
Synthesizing adrenaline in the lab allows for the production of large quantities of the hormone, which can then be used for medical or research purposes.
3. How is adrenaline synthesized in the lab?
Adrenaline can be synthesized in the lab through various methods, including the extraction of the hormone from animal sources or the chemical synthesis of its molecular structure.
4. Is synthetic adrenaline identical to the adrenaline produced by the body?
Yes, synthetic adrenaline is chemically identical to the adrenaline produced by the body, as long as the synthesis process is done correctly.
5. What are the potential applications of synthesized adrenaline?
Synthesized adrenaline can be used in medical treatments for conditions such as severe allergic reactions and asthma attacks, as well as in research studies to better understand the hormone's effects on the body.
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