is any other chemist on here familiar with trying to separate isomers? I hate how tedious it is, after I run a silica gel column, I have to take each fraction evaporate the eluent, dissolve what is left behind in methanol, prepare LC/MS sample, and wait 3.2 min for each sample to run in order to find out which fractions have the isomer i don't want. This is extremely tedious and time consuming when you have about 80+ fractions all for the same compound. you can't see the isomer separate on TLC (the spots will just loot like one spot) so LC/MS is the only way I know of so far that will work. Does anyone on here have a trick up their sleeve and know a more efficient and time saving method to figure out which fractions contain the unwanted isomer?