Main Question or Discussion Point
Does anyone have any secret tricks to get this rxn to go? Usually a secondary amine with a sulfonyl chloride gives the sulfonamide really easily, but I am now trying it w/ methyl amine, which is obviously primary, and it does not want to go at all. I tried dissolving the sulfonyl chloride in ethyl acetate and adding the amine which LC/MS said didn't work. I also tried dissolving the sulfonyl chloride in ethyl acetate, adding 15 eq. of methyl amine, and some DMAP, still without success according to LC/MS. Anyone have any bright ideas on how to get this one to go?