I am currently working on a small personal project to design a few circuits. I am trying to built a circuit that can detect 100 uV pulses with a pulse width of about 10 uS. I'd like to boost the voltage to a value readable by an FPGA (let say ~2 volts). I'm currently thinking about the architecture I want to use to solve this problem. I'd like your input on my approach and maybe some suggestions for other circuit layouts to use. Initially I thought about using a standard instrumentation amplifier layout similar to the one seen in the link below. However I am concerned with the non ideal effects of the op amps. hhttps://upload.wikimedia.org/wikipedia/commons/thumb/e/ed/Op-Amp_Instrumentation_Amplifier.svg/400px-Op-Amp_Instrumentation_Amplifier.svg.png The required gain to get to 2 volts is 20,000. with a CMRR of 100 that would be multiply common mode noise by 200, which could be fairly significant. With the dc offset introduced by the op amps an subsequent amplifier stages would greatly increase any noise, even with a good CMRR. That being said, the best I could come up with is a 2 stage instrumentation amp, followed by another diff amp stage. I have large dc offset and would appreciate any architecture ideas. thanks!