Mismatches & Mutations: Is a Mismatched Base a Mutation?

  • Thread starter bioquest
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In summary, a mismatched base is considered a mutation, but it can still be repaired by the mismatch machinery if the abnormal base pairing is present before DNA replication. It is not possible to detect mutations in cells without killing them, as X-rays cannot penetrate the cell while it is still alive. This is because there would be too much movement in the cell, making it difficult to accurately determine if a mutation is present.
  • #1
bioquest
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please, could someone tell me, is a mismatched base considered a mutation, some or all of the time. somebody kind of confused me on this, they were answering my question through email but I am confused about this one thing
thanks
 
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  • #2
It is a mutation, but it can still be repaired by the mismatch machinery if the abnormal base pairing is still present (before DNA replication).
 
  • #3
I understand you can't see which cells have mutations without killing the cell but why can't you xray the cell or something and see if it has a mutation that way (without killing it) I mean you can xray through solid objects
?
is it because there would be too much movement or something?
 

1. What is a mismatched base?

A mismatched base is a DNA base that does not correctly pair with its complementary base. In DNA, adenine (A) pairs with thymine (T) and guanine (G) pairs with cytosine (C). A mismatched base occurs when there is a different base pairing, such as A with C or G with T.

2. How do mismatched bases occur?

Mismatched bases can occur through errors during DNA replication, DNA damage, or exposure to mutagens. These can result in a base being incorrectly inserted during DNA synthesis, leading to a mismatched base pair.

3. What is a mutation?

A mutation is a permanent change in the DNA sequence of a gene. This can occur due to various factors, including mismatched bases, and can result in alterations to the function or expression of the gene.

4. Is a mismatched base always a mutation?

No, not all mismatched bases result in mutations. In some cases, the cell's DNA repair mechanisms can correct the error and restore the correct base pairing. However, if the mismatched base is not corrected, it can lead to a permanent mutation.

5. Can mismatched bases have any consequences?

Yes, mismatched bases can have consequences such as altering the amino acid sequence of a protein, affecting gene expression, and potentially leading to genetic disorders or diseases. However, mismatched bases can also occur without any noticeable effects on an organism.

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