# Mixed inhibition

1. Feb 17, 2016

### Dassinia

1. The problem statement, all variables and given/known data
I have this mixed inhibition, and knowing that it is a thermodynamic cycle i am asked to find the relation between the different Ki and Ks.
https://scontent.xx.fbcdn.net/hphotos-xfp1/v/t35.0-12/12699252_1024216030972374_1605707906_o.jpg?oh=8b60ba8c953ea368fe8fc09af6fe5eaa&oe=56C77997
2. Relevant equations

3. The attempt at a solution
I am not even sure to understand the question...

Last edited: Feb 17, 2016
2. Feb 17, 2016

### epenguin

Look at the top line only. What is the equilibrium constant between E and ES?
Well okay since you say you don't understand the question Ks = [E][ S]/[ES] = ?

Now rub out to the arrows of the top line. Leave the others. What is the above-defined equilibrium constant equal to?

Can these equilibrium constants be different?

3. Feb 17, 2016

### Dassinia

Between E and ES Ks=k-1/k1 Is it equal to k'-1/k'1=Ks' ?

4. Feb 18, 2016

### epenguin

In general no.

Rub out to the arrows of the top line. Leave the others. In fact just write out the scheme again without the k1, k-1 steps. Can't you work out what that gives you for [E][ S]/[ES] ?