Kill Tumor Cells w/Osmosis: Active Transport Needed?

[sontag]

Could a tumour cell be killed in a person
by making the cell membrane too permeable
to water and so causing tumour cells to swell
and burst.Perhaps active transport of some kind would be
needed to do this?

 

[Monique]

That would be a bad way to kill a cell: you induce necrosis of tissue, which is very messy. The cytoplasm is spilled to the environment, leading to a breading ground of bacteria and causing an inflammation reaction. You can better selectively kill a cell by apoptosis. Researchers are trying to find markers that are specific for tumor cells, but finding one is difficult. Some success has been made in treating melanomas by inducing an immune response to those.

There are medicines available that do exactly what you are suggesting: poking holes in cell membranes against micro-organism that cause illnesses. Your immune system uses the system too, were perforins are excreted from activated cells.

 

[ravenprp]

It is possible that increasing the permeability of a tumour cell's membrane to water could cause the cell to swell and burst, resulting in its death. However, this method would likely not be effective in killing all tumour cells in a person, as tumours often contain a heterogeneous mix of cells with varying levels of permeability. Additionally, this method may also harm healthy cells in the body.

Active transport, which involves the use of cellular energy to move substances against their concentration gradient, may be necessary to specifically target and kill tumour cells. This could potentially be achieved through targeted drug delivery systems that use active transport mechanisms to transport drugs directly to tumour cells. However, further research is needed to fully understand the potential of active transport in killing tumour cells and to develop safe and effective treatments.