Dismiss Notice
Join Physics Forums Today!
The friendliest, high quality science and math community on the planet! Everyone who loves science is here!

P53 mutation

  1. Apr 10, 2010 #1
    Any ideas with this one? It's a part of an optional assignment I have been working on for extra credit. Everything else is complete and I have been milling this one over for about a week without coming up with a solution that I am confident in.

    You are studying a heritable form of cancer that is due to a mutation in the p53 gene. The
    mutation is thought to be a deletion of 200 bases in the middle of the gene.

    You are given a number of tissue samples from an affected male individual which you
    analyse with the test you designed. How many wild type and how many mutant p53
    genes would you expect to find per cell in non-cancerous somatic cells, tumour cells and
    sperm cells?

    I'd use a microarry to do this. Could I figure out mutants based on the two hit theory?
  2. jcsd
  3. Apr 11, 2010 #2
    I would use the 2 hit theory. Isnt the whole "non-cancerous somatic cells" phrase a hint for that
Share this great discussion with others via Reddit, Google+, Twitter, or Facebook