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Biology and Medical
Partial Reprogramming and Rejuvenation
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[QUOTE="FTM1000, post: 6479855, member: 535399"] Just found an answer about the endurance of the results from partial reprogramming: [URL]https://link.springer.com/article/10.1007/s11357-021-00358-6[/URL] in "Table 1 Studies of partial epigenetic reprogramming" there is a table with experiment on partial reprogramming and the duration of their effects and in most cases the effects only lasted for several days. Now I have a different question, is there anything in this article that suggest a possible reason for why those changes doesn't last? or a way to make those changes permanent?. The article does say that partial reprogramming hold a great promise for treating aging, and it also suggest the following: "A suggestion is an approach similar to the one shown by Ocampo et al. [[URL='https://link.springer.com/article/10.1007/s11357-021-00358-6#ref-CR28']28[/URL]], but with the inclusion of a treatment that enhances genome stability during the absence of pluripotency factor expression. Short expression of pluripotency factors followed by administration of metformin, rapamycin, or even resveratrol would slightly flip the epigenetic landscape followed by the formation of deeper grooves. Perhaps this procedure would both improve lifespan extension and hinder the development of cancer and senescent cells.". does this have anything to do with making the results of the partial reprogramming more permanent?. [/QUOTE]
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