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Particle Sizing using Dynamic Light Scattering (DLS) - Volume, Intensity & Number?

  1. Aug 12, 2010 #1
    Equipment: Nicomp 380ZLS&S Sub-micron Particle Sizer &
    Malvern Mastersizer X

    Material: Ophthalmic Suspension, viscous and opaque

    When installing these instruments the technician started explaining why the Volume weighting was the most representative measurement for what I'm testing.

    For example, if the suspension or emulsion average particle diameter is 500nm the volume weighting will read around 500nm and the intensity weighting will read a little lower - maybe 300-400nm, then the number weighting will read very low - less than 100nm.

    Why are these weightings so different? Is it my sample preparation? Can anyone explain why volume should be my representative reading and not intensity or number?

    D. Wilkerson
  2. jcsd
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