Can someone help me understand this statement: The pKa of most fatty acids is around 4.5, so most fatty acids exist in their anion form in the cellular environment. I know what a pKa is... it is -log(Ka), where Ka is the equilibrium constant of the reaction. In this case the Ka would be 3 x 10^(-5). Also I understand that the larger the Ka, the stronger the acid strength (the more it would dissociate). How do we know that a Ka of 3 x 10-5 is a large Ka?