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Polyclonal antiserum?

  1. Mar 22, 2005 #1
    What is polyclonal antiserum? I have checked the net, but could not find any good explanation on it. :grumpy:

    Thanks.
     
  2. jcsd
  3. Mar 22, 2005 #2

    Monique

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    You should be looking for polyclonal antibodies: they recognize multiple epitopes, making them more robust to small changes in the antigen. Monoclonal antibodies react only to one epitope, making them highly specific, but they are more expensive and take longer to develop.
     
  4. Mar 22, 2005 #3
    So polyclonal antiserum is the same as polyclonal antibodies? :uhh:
     
  5. Mar 22, 2005 #4

    Monique

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    You immunize an animal with an antigen, after which you isolate blood and get serum from that. That is your antiserum that will contain antibodies to the antigen. You can purify the serum with protein A, or protein G, depending on the chemistry.
     
    Last edited: Mar 22, 2005
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