1. The problem statement, all variables and given/known data Dolor and her cousin Largo have conceived a child. They are very concerned about the baby, because they have heard that children of close relatives have a higher incidence of birth defects and/or inherited recessive disorders. They know that their maternal grandmother was a carrier of the Herrera syndrome allele. Assuming that this is the only source of genetic problems for Dolor and Largo, what is the chance that they are both carriers ? a. 1 in 16 b. 1 in 4 c. 1 in 8 d. 1 in 106 e. 1 in 2 2. Relevant equations See below. 3. The attempt at a solution Each grandchild has ¼ probability of carrying one of four original alleles from grandparents, so the probability of both being carriers is (¼)* (1/4) = 1/16? 1. The problem statement, all variables and given/known data The chance that Dolor and Largo will have a child with Herrera’s syndrome is a. 1 in 4 b. 1 in 64 c. 1 in 32 d. 1 in 16 e. 1 in 12 2. Relevant equations See below. 3. The attempt at a solution For the great-grandchild there is a 1/8 probability (of gametes) for getting a recessive allele, so (1/8) * (1/8) = 1/64? Thank you for any help.