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Pyruvate decarboxylation

  1. Jan 13, 2010 #1
    After glycolysis where is pyruvate converted to Acetyl-CoA? I know pyruvate can't enter the citric acid cycle but does the pyruvate molecule make its way into the matrix of the mitochondria then get converted to Acetyl-CoA or does it have to be converted before it can even cross the membranes of the mitochondrion?
  2. jcsd
  3. Jan 13, 2010 #2
    Pyruvate decarboxylation occurs in the mitochondrial matrix.
  4. Jan 14, 2010 #3
  5. Jan 25, 2010 #4
    The way around mitochondrion is glyceraldehyde and malate-oxaloacetate shuttles. You might want to check this out in wikipedia.
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