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Ribose and Deoxyribose

  1. Apr 23, 2007 #1


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    Here is a drawing of Ribose and 2-deoxyribose.
    My question is this the most common form of deoxyribose? Is it common to find 3 or 4 deoxyrybose?

    My guess is that this is the most common because of stabilization from the double bond on the oxygen..... but just want to double check. Thanks!


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  3. Apr 24, 2007 #2


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    The enzyme ribonucleotide reductace is responsible for the reduction reaction for the ribonucleotides. It consists of two domains (subunits). The reduction is a free radical process. One of the domains generates the free radical and the other binds to the ribose sugar and accepts the free radical. The free radical (a sulfhydryl group) abstracts a hydrogen from the C-3' of the ribose and promotes the release of the hydroxyl on the C-2' of the ribose. The C-2' position accepts a hydride from the enzyme and pushes the radical back to the C-3' position which is reprotonated by the same sulfhydryl that produced the radical in the first step.

    The double bond to oxygen is important to the energetics but the enzyme binding/shape is important to the regiochemistry.
  4. Apr 24, 2007 #3


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    Thanks! outstanding
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