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RNA and Histones

  1. Mar 20, 2004 #1
    Hey,

    I'm just wondering if it would be possible for a RNA duplex wrap itself around a histone, like a DNA duplex can ? My personal guess is that it should be able to do so, since the differences between RNA and DNA aren't that large (2'-OH and one different base).

    What do you guys think ?
    Thanks,
     
  2. jcsd
  3. Mar 20, 2004 #2

    Monique

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    The RNA base might not be that different, but the way the molecule folds into a helix and the way it forms a three-dimensional molecule with lots of hairpins is actually very different from DNA.
     
  4. Mar 20, 2004 #3
    Do you know if any research has been done on this subject ? Maybe something that would be found online ?

    Thanks,
     
  5. Mar 20, 2004 #4

    Monique

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    Well, actually RNA does not form a double stranded helix like DNA does. Eukaryotic organisms have a defensive mechanism by which they break down dsRNA, because viruses DO use dsRNA (thus it is recognized as foreign). Rather RNA forms very complex internal hybridizations, a simple example here. So RNA does not form a duplex, but more a complex stem-loop structure.

    Thus I'd think it won't wrap around a histone (but I have to admit I don't know too much about dna-histone interaction (which now I'm going to change soon)).
     
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