I am thinking about the process to pick up a thesis for a bioinformatics like this 1. State what I want: I would like to do a research about protein folding 2. State what can be done with it: A lot, but I will concentrate on its structure and a specific disease related to human beings. 3. State how its folding issue leading to the disease: I will build a simulation program for this 4. Explain how can it be *fixed* virtually: I don't know at present. But of course I have to build another program to simulate how the input data correct the issue in question. Is there anything wrong about my workflow to produce a thesis ("Visualization of disease XXX at the protein structure level") ? Thank you bears a lot.