Advantages of Larger Syringe Barrels for Aspiration & Pathology Removal

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In summary, the conversation is discussing the potential advantages of using a larger diameter barrel syringe in aspiration procedures. The questions revolve around the difference in aspiration between a 29mm and 40mm barrel, the speed of aspiration for liquids and solids, and the potential for a new syringe design to provide greater negative pressure force. The conclusion is that there may be a slight advantage in the initial aspiration while the catheter lumen is being filled with fluid, but overall the suction force will be the same regardless of barrel diameter.
  • #1
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We need to figure out the advantage, if any, of using a larger diameter barrel syringe to aspirate fluid and pathology (cells, blood clot & tissue) from a patient using identical size catheters or needles.

Lets ignore that, all things equal, it takes more force to pull back a larger plunger for the momement. The below will be using identical 100cm catheters with 1.5mm inner lumens.

1. What will the aspiration difference be between a syringe barrel with a 29mm and a 40mm diameter if each have an identical 40mm stroke (plunger travel)?
2. Will the larger barrel pull liquids or solids faster through a catheter if connected to a catheter and the plunger is pulled back once?
3. Consider that we can put an automatic three-way valve on the tip of the syringe. The valve will open to suction from a catheter when the plunger is pulled back to aspirate, then the valve will automatically close to the catheter and open to a drain bag to eject the fluid/pathology in the barrel when the plunger is pushed back in. A user can then pulse the plunger open and closed to pull aspiration/drain. Given this 3-way valve, will a 29mm or a 40mm barrel give more suction-aspiration force?

We know of a new syringe design that allows physicians to pull negative pressure easier than before and are tying to hypothesis the benefits of it's use in aspiration biopsy and thrombus removal. For example, if the plunger is all the way pushed in on the 40mm diameter syringe and the tip is sealed, I cannot pull the plunger back with two hands using a traditional syringe design. But, with this new design, a child can pull back the plunger with one-hand on the 40mm diameter design. Knowing that we max out at 1atm of vacuum, what will the advantage be besides more volume. Can we get more aspiration, suction or negative pressure force?
 
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  • #2
There will be an advantage only on the first aspiration while the air in the catheter lumen is being replaced by sample fluid. That advantage will be minor as air is much easier to draw than a liquid. The rate will be quite independent of the syringe diameter once the lumen is filled with sample fluid. That is because the atmospheric pressure limit is independent of syringe diameter, so the suction force moving fluid along the catheter is constant.
 

1. What are the benefits of using larger syringe barrels for aspiration and pathology removal?

Using larger syringe barrels for aspiration and pathology removal allows for a higher volume of fluid or tissue to be extracted in one go, reducing the need for multiple aspirations. This can save time and increase efficiency, especially in cases where a large amount of fluid or tissue needs to be removed.

2. How does the size of the syringe barrel affect the accuracy and precision of aspiration and pathology removal?

Larger syringe barrels have a larger diameter, which allows for a larger plunger and more leverage. This can make it easier to control the speed and pressure of aspiration, resulting in improved accuracy and precision. Additionally, the larger size allows for a smoother and more consistent flow of fluid, reducing the risk of clogging or uneven aspiration.

3. Are there any potential risks associated with using larger syringe barrels for aspiration and pathology removal?

While larger syringe barrels offer many advantages, it is important to note that they also require a certain level of skill and experience to be used effectively. Inexperienced users may struggle to maintain control over the larger size and increased pressure, which could potentially lead to tissue damage or other complications. It is important to receive proper training and adhere to safety guidelines when using larger syringe barrels.

4. How do larger syringe barrels compare to smaller ones in terms of cost?

In general, larger syringe barrels tend to be more expensive than smaller ones due to the larger amount of material required to manufacture them. However, the cost may vary depending on the specific brand and type of syringe. Additionally, the potential time and efficiency savings of using larger syringe barrels may outweigh the initial cost difference.

5. Are there any other situations in which larger syringe barrels may be beneficial for aspiration and pathology removal?

Aside from the obvious advantage of larger volumes, larger syringe barrels may also be useful in cases where a high level of precision is required, such as in delicate procedures or when removing small amounts of fluid from hard-to-reach areas. Additionally, the increased pressure and leverage provided by larger syringe barrels may be beneficial for removing denser or thicker substances.

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